Open AccessNanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective
Author(s) -
Anggraini Barlian,
Katherine Vanya
Publication year - 2022
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2021-0097
Subject(s) - mesenchymal stem cell , nanotopography , downregulation and upregulation , microbiology and biotechnology , cellular differentiation , tissue engineering , stem cell , in vivo , chemistry , medicine , biomedical engineering , biology , biochemistry , gene
Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the role of nanopatterns in directing or inducing MSC osteogenic differentiation, especially in bone tissue engineering. Nanopatterns can upregulate the expression of osteogenic markers, which indicates a faster differentiation process. Combined with growth factors, nanopatterns can further upregulate osteogenic markers, but with fewer growth factors needed, thereby reducing the risks and costs involved. Nanopatterns can be applied in scaffolds for tissue engineering for their lasting effects, even in vivo, thus having great potential for future bone treatment.