Open AccessGlobal thrombosis test for assessing thrombotic status and efficacy of antithrombotic diet and other conditions
Author(s) -
Masahirô Murakami,
Kazunori Otsui,
Yoshinobu Ijiri,
Masaharu Shimizu,
Hideo Ikarugi,
Wataru Shioyama,
Junichiro Yamamoto,
Kjell S. Sakariassen
Publication year - 2022
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2021-0086
Subject(s) - antithrombotic , medicine , thrombosis , fibrinolysis , platelet , coagulation , stroke (engine) , fibrinolytic agent , intensive care medicine , cardiology , mechanical engineering , engineering
Because of the high mortality from myocardial infarction and stroke, there is a great demand for finding novel methods of diagnosis, prevention and treatment of these diseases. Most of the current tests measure important determinants of thrombosis such as platelet function, coagulation and fibrinolysis in isolation; therefore, a global test measuring the actual thrombotic status would be more useful in clinical conditions. We obtained considerable experience by using the global thrombosis test, which determines the actual thrombotic status by taking into account the measured platelet reactivity, coagulation and fibrinolytic activities. In animal experiments, we found significant correlation between the ex vivo global thrombosis test measurements and the in vivo thrombotic status. The published evidence for the benefit of an antithrombotic diet with regular physical exercise is also described.