Open AccessEffectiveness of intra-articular autologous-conditioned serum injection in knee osteoarthritis: a meta-analysis study
Author(s) -
Seyed Ahmad Raeissadat,
Seyed Mansoor Rayegani,
MohammadReza Sohrabi,
Nafisseh Jafarian,
Mohammad Hasan Bahrami
Publication year - 2021
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2021-0069
Subject(s) - womac , osteoarthritis , medicine , visual analogue scale , meta analysis , strictly standardized mean difference , physical therapy , significant difference , mean difference , confidence interval , pathology , alternative medicine
Aim: Knee osteoarthritis is a common disabling disorder, with no curative treatment. This study aims to assess autologous conditioned serum effectiveness in its treatment. Materials & methods: Following a systematic search (2000–2020) on major databases and screening and filtering processes, eight articles were included in the final analyses. The pooled effect of visual analog scale (VAS) and the Western Ontario and McMaster Universities (WOMAC) variables was evaluated before and after the intervention. Results: The combined standardized mean difference for the global WOMAC score was -2.44 and the combined weighted mean difference was -22.92. The combined standardized mean difference for the VAS score was -3.77 and the combined weighted mean difference was -32.37 (p < 0.000). Conclusion: This meta-analysis reported that the autologous conditioned serum can reduce pain and improve function (VAS and WOMAC outcome measures) in patients with knee osteoarthritis.