Open AccessDemography, patterns of care, and survival outcomes in patients with salivary duct carcinoma: an individual patient data analysis of 857 patients
Author(s) -
Prashanth Giridhar,
Bhanu Prasad Venkatesulu,
Ryan Yoo,
V Pragathee,
Goura Kishor Rath,
Supriya Mallick,
Ashishdutt Upadhyay,
Ding Cheng Chan
Publication year - 2022
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2021-0052
Subject(s) - medicine , salivary duct carcinoma , malignancy , adjuvant radiotherapy , oncology , cohort , adjuvant , overall survival , survival analysis , radiation therapy , carcinoma
Aim: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy. The optimal treatment protocols are debated. Methodology: A systematic search and individual patient data analysis of published cases of SDC was performed. SPSS v21 was used for statistical analysis. Results: Data of 857 patients available. Median overall survival (OS) and progression-free survival (PFS) of the entire cohort 42 months and 24 months. Nodal involvement, males, primary size >5 cm, androgen receptor (AR) negativity significantly worse OS. Patients with surgery had a favorable median PFS (p = 0.000) and OS (p = 0.077). Patients with adjuvant radiation had better PFS (30 vs 18 months; p = 0.077). Conclusion: SDC has modest survival. Surgery and adjuvant radiation should be advocated for all patients. AR expression appears prognostic for survival.