The Role and Underlying Mechanism of miR-1299 in Cancer | Zendy

Kaiyuan Deng | Zendy; Lijuan Huang | Zendy; Xueyuan Sun | Zendy; Yunhui Zang | Zendy

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The Role and Underlying Mechanism of miR-1299 in Cancer

Author(s) -

Kaiyuan Deng,

Lijuan Huang,

Xueyuan Sun,

Yunhui Zang

Publication year - 2021

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.2144/fsoa-2021-0014

Subject(s) - microrna , carcinogenesis , biology , transcription factor , suppressor , angiogenesis , gene , cell growth , endogeny , cancer research , transcription (linguistics) , microbiology and biotechnology , genetics , linguistics , philosophy , endocrinology

A type of evolutionarily conserved, noncoding, small, endogenous, single-stranded RNA, miRNAs are widely distributed in eukaryotes, where they participate in various biological processes as critical regulatory molecules. miR-1299 has mainly been investigated in cancers. miR-1299 is a tumor suppressor that regulates the expression of its target genes, activating or inhibiting the transcription of genes regulating biological activities including cell proliferation, migration, survival and programmed cell death. miR-1299 has become a hotspot in research of disease mechanisms and biomarkers; elucidation of the regulatory roles of miR-1299 in tumorigenesis, proliferation, apoptosis, invasion, migration and angiogenesis may provide a new perspective for understanding its biological functions as a tumor suppressor.

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