Open AccessThe role and underlying mechanism of miR-1299 in cancer
Author(s) -
Kaiyuan Deng,
Lijuan Huang,
Xueyuan Sun,
Yunhui Zang
Publication year - 2021
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2021-0014
Subject(s) - microrna , carcinogenesis , transcription factor , suppressor , angiogenesis , biology , gene , cell growth , endogeny , cancer research , transcription (linguistics) , microbiology and biotechnology , genetics , linguistics , philosophy , endocrinology
A type of evolutionarily conserved, noncoding, small, endogenous, single-stranded RNA, miRNAs are widely distributed in eukaryotes, where they participate in various biological processes as critical regulatory molecules. miR-1299 has mainly been investigated in cancers. miR-1299 is a tumor suppressor that regulates the expression of its target genes, activating or inhibiting the transcription of genes regulating biological activities including cell proliferation, migration, survival and programmed cell death. miR-1299 has become a hotspot in research of disease mechanisms and biomarkers; elucidation of the regulatory roles of miR-1299 in tumorigenesis, proliferation, apoptosis, invasion, migration and angiogenesis may provide a new perspective for understanding its biological functions as a tumor suppressor.