Open AccessCirculating miRNAs as early indicators of diet and physical activity response in women with metastatic breast cancer
Author(s) -
Jessica Olson,
Patricia M. Sheean,
Lauren Matthews,
Christopher R. Chitambar,
Anjishnu Banerjee,
Alexis Visotcky,
Marcelo G. Bonini,
Melinda Stolley
Publication year - 2021
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2020-0208
Subject(s) - metastatic breast cancer , medicine , downregulation and upregulation , breast cancer , microrna , oncology , cancer , disease , biology , gene , biochemistry
Treatments for metastatic breast cancer (MBC) improve survival but often impose prolonged symptom burden. We performed molecular characterization of 84 miRNAs in the circulating serum of women with MBC to explore possible early indicators of intervention response. Expression levels of miR-10a-5p and miR-211-5p were downregulated in nonresponders, but upregulated in responders (miR-10a-5p: 0.40-fold and eightfold; miR 211-5p: 0.47-fold and fourfold). miR-205-5p expression was upregulated in both nonresponders and responders, but to a greater extent in responders (1.8-fold and sixfold). Additionally, levels of miR-10a-5p were negatively correlated with expression levels of IL-6 (r = -0.412). Exploration of these pathways may reveal mechanisms of action in lifestyle interventions aimed at improving quality of life and impacting disease progression for women with MBC.