Open AccessLow-dose colchicine prevents sympathetic denervation after myocardial ischemia-reperfusion: a new potential protective mechanism
Author(s) -
Fabien Huet,
Jérémy Fauconnier,
Marion Legall,
Pierre Sicard,
Catherine Lozza,
Alain Lacampagne,
François Roubille
Publication year - 2021
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2020-0151
Subject(s) - colchicine , medicine , denervation , cardiology , ischemia , myocardial infarction , reperfusion injury , anesthesia , sympathetic nervous system , sympathectomy , pharmacology , blood pressure
Purpose: To evaluate the impact of colchicine on sympathetic denervation after acute myocardial infarction (AMI). Materials & methods: Ischemia/Reperfusion was induced in C57BL/6J male mice. Left coronary artery was ligated during 45 min followed by reperfusion. 400 μg/kg of colchicine or the placebo was administrated intraperitoneally 15 min before the reperfusion. Results: Colchicine treatment significantly improved heart rate variability index after AMI. Colchicine prevented sympathetic denervation in the remote area (p = 0.04) but not in the scar area (p = 0.70). Conclusion: These results suggest promising protective pathway of colchicine after AMI.