Open AccessSurvival and glycemic control in patients with co-existing squamous cell carcinoma and diabetes mellitus
Author(s) -
Sophia A. Ederaine,
Johanny Lopez Dominguez,
Jamison A. Harvey,
Aaron R. Mangold,
Curtiss B. Cook,
Heidi E. Kosiorek,
Matthew Buras,
Kyle Coppola,
Nina J. Karlin
Publication year - 2021
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2020-0150
Subject(s) - glycemic , medicine , diabetes mellitus , basal cell , overall survival , gastroenterology , survival analysis , cancer , hemoglobin , oncology , endocrinology
Aim: This study examined the impact of diabetes mellitus (DM) on survival in squamous cell carcinoma (SCC) patients, and the impact of SCC on glycemic control. Materials & methods: Patients with newly diagnosed SCC with and without DM were matched 1:1 (2007–2017). Overall survival and recurrence-free survival were estimated using the Kaplan–Meier method. Hemoglobin A 1c (HbA 1c ) and glucose level during the year following cancer diagnosis were compared using mixed models. Results: HbA 1c decreased over time in DM patients (p = 0.04). The 5-year overall survival was 61% in DM patients, compared with 78% in patients without DM (p = 0.004). Conclusion: The presence of co-existing DM adversely impacted survival in patients with SCC. SCC did not affect glycemic control.