Open AccessCurcumin micelles entrapped in eudragit S-100 matrix: a synergistic strategy for enhanced oral delivery
Author(s) -
Helmy Yusuf,
Resti Yuliana Rahmawati,
M. Agus Syamsur Rijal,
Dewi Isadiartuti
Publication year - 2021
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2020-0131
Subject(s) - bioavailability , micelle , poloxamer , curcumin , chemistry , dissolution , solubility , chromatography , chemical engineering , poloxamer 407 , amorphous solid , materials science , nuclear chemistry , pharmacology , polymer , organic chemistry , aqueous solution , medicine , biochemistry , copolymer , engineering
Background: Therapeutic activities of curcumin (CUR) via oral administration are hampered by the lack of bioavailability due to its poor water solubility and rapid degradation in GI tract. Materials & methods: This preliminary study developed CUR micelle-eudragit S100 (EUD) dry powder (CM-EDP) spray-dried formulations. Poloxamer 407 was used as a micelle-forming agent and EUD as an entrapping matrix for protection over hydrolysis and enzymes in the GI tract. Results: The morphology of CM-EDP showed agglomeration with cratering on the surface of particles. Differential thermal analysis and x-ray diffractometry data exhibited evidence that CUR was converted into amorphous solid. An increased concentration of micelle-forming and dispersion matrix polymers resulted in a high fraction of drug being converted into the amorphous state. A significant increase in dissolution by 7–10 times was achieved compared with that of raw CUR. Conclusion: The present study disclosed the CM-EDP potency for future development of CUR oral formulation.