Open AccessNonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition
Author(s) -
Antonela Del Giúdice,
Lucas Pagura,
María Celeste Capitani,
Leandro E. Mainetti,
O. Graciela Scharovsky,
Ricardo José Di Masso,
María José Rico,
Viviana R. Rozados
Publication year - 2020
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2019-0108
Subject(s) - immunoediting , immune system , interleukin 10 , biology , univariate , immunology , interleukin , cancer research , multivariate statistics , medicine , immunotherapy , cytokine , mathematics , statistics
Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Results & conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response.