Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition | Zendy

Antonela Del Giúdice | Zendy; Lucas Pagura | Zendy; María C. Capitani | Zendy; Leandro E. Mainetti | Zendy; O. Graciela Scharovsky | Zendy; Ricardo José Di Masso | Zendy; María J. Rico | Zendy; Viviana R. Rozados | Zendy

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Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition

Author(s) -

Antonela Del Giúdice,

Lucas Pagura,

María C. Capitani,

Leandro E. Mainetti,

O. Graciela Scharovsky,

Ricardo José Di Masso,

María J. Rico,

Viviana R. Rozados

Publication year - 2020

Publication title -

future science oa

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 23

ISSN - 2056-5623

DOI - 10.2144/fsoa-2019-0108

Subject(s) - immunoediting , immune system , interleukin 10 , biology , univariate , immunology , interleukin , cancer research , multivariate statistics , medicine , immunotherapy , cytokine , mathematics , statistics

Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting. Materials & methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma. Results & conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response.

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