Open AccessA review on bacterial resistance to carbapenems: epidemiology, detection and treatment options
Author(s) -
Ann A Elshamy,
Khaled M. Aboshanab
Publication year - 2020
Publication title -
future science oa
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 23
ISSN - 2056-5623
DOI - 10.2144/fsoa-2019-0098
Subject(s) - carbapenem resistant enterobacteriaceae , carbapenem , epidemiology , antibiotic resistance , enterobacteriaceae , antimicrobial , multiple drug resistance , microbiology and biotechnology , outbreak , drug resistance , intensive care medicine , medicine , biology , antibiotics , virology , escherichia coli , genetics , gene
Carbapenems are a class of antimicrobial agents reserved for infections caused by multidrug-resistant microorganisms. The emergence of carbapenem resistance has become a serious public health threat. This type of antimicrobial resistance is spreading at an alarming rate, resulting in major outbreaks and treatment failure of community-acquired and nosocomial infections caused by the clinically relevant carbapenem-producing Enterobacteriaceae or carbapenem-resistant Enterobacteriaceae . This review is focused on carbapenem resistance, including mechanisms of resistance, history and epidemiology, phenotypic and genotypic detection in the clinically relevant bacterial pathogens and the possible treatment options available.