Open AccessConventional and innovative methods to assess oxidative stress biomarkers in the clinical cardiovascular setting
Author(s) -
Melania Gaggini,
Laura Sabatino,
Cristina Vassalle
Publication year - 2020
Publication title -
biotechniques/biotechniques
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 131
eISSN - 1940-9818
pISSN - 0736-6205
DOI - 10.2144/btn-2019-0138
Subject(s) - oxidative stress , medicine , disease , biomarker , bioinformatics , clinical practice , pathophysiology , oxidative phosphorylation , computational biology , pathology , biology , biochemistry , physical therapy
Oxidative stress has a pivotal and widely described role in the onset and progression of atherosclerotic plaque and cardiovascular disease. Many oxidative stress-related biomarkers can be measured in biological samples; however, there are still many aspects that limit the adoption of oxidative stress assessment in clinical laboratory practice. Here, we report an overview of the different sources and main common oxidative stress biomarkers relevant for cardiovascular physiopathology, describing in detail a recently proposed lipidomic assay for ceramide assessment, as a promising future development in oxidative stress evaluation among the many available redox-related tests.