Open AccessMicroarrays—Solutions to the Protein Challenge
Author(s) -
Jeremy Clarke
Publication year - 2005
Publication title -
biotechniques/biotechniques
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.617
H-Index - 131
eISSN - 1940-9818
pISSN - 0736-6205
DOI - 10.2144/05381af02
Subject(s) - computational biology , proteome , automation , dna microarray , oligonucleotide , protein microarray , computer science , miniaturization , complementary dna , biology , protein expression , data science , bioinformatics , nanotechnology , genetics , gene expression , dna , gene , engineering , mechanical engineering , materials science
The study of the proteome presents many challenges to the researcher. One of these is finding the best way to study tens of thousands of proteins in as short a time as possible. With the advances in miniaturization and automation over the recent past, several approaches are now available for producing high-density protein arrays on custom slides. After the arraying process is complete, lessons learned in the automated hybridization and imaging of cDNA and oligonucleotides now allow the consistent high-throughput study of antibody/antigen interactions.