Open AccessThe Role of BAALC-Expressing Leukemia Precursor Cells in the Pathogenesis of Myelodysplastic Syndromes
Author(s) -
Н Н Мамаев,
M.V. Latypova,
A.I. Shakirova,
Т. Л. Гиндина,
Мikhail Кanunnikov,
Nikolai Tsvetkov,
Ildar Barkhatov,
Sergey N. Bondarenko,
Maria Vladovskaya,
Е. В. Морозова
Publication year - 2022
Publication title -
kliničeskaâ onkogematologiâ
Language(s) - English
Resource type - Journals
eISSN - 2500-2139
pISSN - 1997-6933
DOI - 10.21320/2500-2139-2022-15-1-62-68
Subject(s) - karyotype , myelodysplastic syndromes , myeloid leukemia , clone (java method) , leukemia , biology , pathogenesis , haematopoiesis , gene expression profiling , cytogenetics , myeloid , cancer research , locus (genetics) , gene , immunology , genetics , gene expression , stem cell , chromosome , bone marrow
The present paper provides evidence for a high detection rate of BAALC gene overexpression, also combined with WT1 gene overexpression, in patients with myelodysplastic syndromes (MDS) and FISH-verified chromosome defects. The BAALC and WT1 gene expression profiling of 16 MDS patients (6 out of them received allogeneic hematopoietic stem cell transplantation) showed an increased BAALC expression in 14 patients. The expression level in 2 patients was near the cut-off. Low expression levels were identified in a female patient with isolated 5q deletion in karyotype and also with its combination with complex karyotype. On the other hand, the highest expression levels were reported in patients with normal karyotype and 3q26 locus rearrangement, which was associated with EVI1 gene overexpression. Since the BAALC expression level, at least in patients with the major (except for М3 and М7) FAB-variants of acute myeloid leukemias (AML), was closely associated with BAALC-producing precursor cells of leukemia clone, a profound study of this phenomenon in MDS patients seems to be important for understanding the finest mechanisms underlying the pathogenesis of AML and AML relapses on the level of precursor cells.