Open AccessChronic Lymphocytic Leukemia in Blood Relatives: Two Case Reports of Male Siblings
Author(s) -
Nadezhda Viktorovna Kurkina,
E.A. Repina
Publication year - 2021
Publication title -
kliničeskaâ onkogematologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.116
H-Index - 2
eISSN - 2500-2139
pISSN - 1997-6933
DOI - 10.21320/2500-2139-2021-14-1-69-72
Subject(s) - chronic lymphocytic leukemia , medicine , ibrutinib , lymphoma , lymphoproliferative disorders , leukemia , hematology , immunology , oncology
In recent years there are more and more evidences for a hereditary factor in malignant lymphoproliferative disorders. Various lymphoid tumors are diagnosed in blood relatives. This is most frequently observed in chronic lymphocytic leukemia: 13.3 % vs. 8.8 % in non-Hodgkin’s lymphoma and 5.9 % in Hodgkin’s lymphoma. This paper presents two case reports of chronic lymphocytic leukemia in blood relatives (male siblings). Besides, in one of them the efficacy of targeted therapy with ibrutinib is estimated.