Open AccessCurrent View on Diagnosis and Treatment of Classical Ph-Negative Myeloproliferative Neoplasms
Author(s) -
AL Melikyan,
И Н Суборцева,
Vasiliy Shuvaev,
Е Г Ломаиа,
Elena Morozova,
Л А Кузьмина,
Olga Vinogradova,
Andrey Zaritskey
Publication year - 2021
Publication title -
kliničeskaâ onkogematologiâ
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.116
H-Index - 2
eISSN - 2500-2139
pISSN - 1997-6933
DOI - 10.21320/2500-2139-2021-14-1-129-137
Subject(s) - essential thrombocythemia , polycythemia vera , myelofibrosis , etiology , medicine , disease , intensive care medicine , myeloproliferative disorders , bone marrow
Classical Ph-negative myeloproliferative neoplasms (MPN) constitute a group of diseases including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Over the past decade, the approaches to understanding of MPN pathogenesis and therapy have considerably changed. At the same time, etiological factors and pathophysiological mechanisms of disease progress are being thoroughly studied. The improvement of diagnosis methods and new approaches to therapy can reduce complications and mortality risks. The review outlines the current diagnosis methods, such as the molecular genetic one, and provides prognostic scores. Different methods of conservative therapy are assessed. Special attention is paid to quality of life measurement and targeted treatment of patients.