Open AccessIs the Mitochondrial Function of Keloid Fibroblasts Affected by Cytoglobin?
Author(s) -
Sri Widia A. Jusman,
Isma Nur Azzizah,
Mohamad Sadikin,
Novi Silvia Hardiany
Publication year - 2021
Publication title -
the malaysian journal of medical sciences/the malaysian journal of medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 25
eISSN - 2180-4303
pISSN - 1394-195X
DOI - 10.21315/mjms2021.28.2.4
Subject(s) - keloid , mitochondrial biogenesis , mitochondrion , microbiology and biotechnology , biology , small interfering rna , coactivator , chemistry , cancer research , biochemistry , rna , transcription factor , pathology , medicine , gene
A keloid is a benign skin tumour characterised by excessive proliferation of fibroblasts, a process that requires a sufficient amount of energy. The energy needs are associated with adequate oxygen (O 2 ) flow and well-functioning mitochondria. It is known that cytoglobin (CYGB) has a function in O 2 distribution. The aim of the present study was to explore whether the inhibition of CYGB expression caused impaired mitochondrial function of keloid fibroblasts.