Open AccessGene Expression of Molecules Regulating Apoptotic Pathways in Glioblastoma Multiforme Treated with Umbilical Cord Stem Cell Conditioned Medium
Author(s) -
Novi Silvia Hardiany,
Edward Christopher Yo,
Eko Ngadiono,
Septelia Inawati Wanandi
Publication year - 2019
Publication title -
the malaysian journal of medical sciences/the malaysian journal of medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 25
eISSN - 2180-4303
pISSN - 1394-195X
DOI - 10.21315/mjms2019.26.6.4
Subject(s) - survivin , apoptosis , downregulation and upregulation , mesenchymal stem cell , stem cell , cancer research , messenger rna , microbiology and biotechnology , cell culture , biology , chemistry , cell , gene , biochemistry , genetics
Glioblastoma multiforme (GBM) is the most malignant primary brain tumour and there is no definite cure. It has been suggested that there are significant interactions among mesenchymal stem cells (MSCs), their released factors and tumour cells that ultimately determine GBM's growth pattern. This study aims to analyse the expression of molecules involved in GBM cell apoptotic pathways following treatment with the MSC secretome.