Open AccessProtective Effects of N-Acetyl-L-Cysteine on the Density of Spiral Ganglion Cells and Histological Changes Induced by Continuous Noise Exposure in Rats
Author(s) -
Raheleh Hashemi Habybabady,
Seyed Bagher Mortazavi,
Ali Khavanin,
Ramazan Mirzaei,
Mohamed G. Arab,
Behzad Mesbahzadeh,
Mehran Hoseini,
Mahdi Mohammadi
Publication year - 2018
Publication title -
the malaysian journal of medical sciences/the malaysian journal of medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 25
eISSN - 2180-4303
pISSN - 1394-195X
DOI - 10.21315/mjms2018.25.5.5
Subject(s) - spiral ganglion , histopathology , cochlea , noise induced hearing loss , noise exposure , saline , medicine , modiolus (cochlea) , basal (medicine) , anatomy , pathology , hearing loss , audiology , insulin
Noise exposure causes loss of cochlea hair cells, leading to permanent sensorineural hearing loss, and initiates pathological changes to the bipolar primary auditory neurons (ANs). This study focuses on the effects of N-acetyl-l-cysteine (NAC) in protecting the density of spiral ganglion cells and in histological changes induced by continuous noise exposure in rats.