Role of Pre-Synaptic NMDA Receptors in the Modulation of Inhibitory Synaptic Transmission in Sensory-Motor and Visual Cortical Pyramidal Neurons in Brain Slices of Young Epileptic Mice | Zendy

Muhammad Hanif Che Lah | Zendy; Faruque Reza | Zendy; Tahamina Begum | Zendy; Jafri Malin Abdullah | Zendy

Open Access

Role of Pre-Synaptic NMDA Receptors in the Modulation of Inhibitory Synaptic Transmission in Sensory-Motor and Visual Cortical Pyramidal Neurons in Brain Slices of Young Epileptic Mice

Author(s) -

Muhammad Hanif Che Lah,

Faruque Reza,

Tahamina Begum,

Jafri Malin Abdullah

Publication year - 2018

Publication title -

malaysian journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.394

H-Index - 25

eISSN - 2180-4303

pISSN - 1394-195X

DOI - 10.21315/mjms2018.25.3.4

Subject(s) - epileptogenesis , neuroscience , inhibitory postsynaptic potential , pilocarpine , neurotransmission , gabaergic , sensory system , nmda receptor , visual cortex , motor coordination , synapse , status epilepticus , chemistry , epilepsy , biology , receptor , medicine

Previous studies from animal models have shown that pre-synaptic NMDA receptors (preNMDARs) are present in the cortex, but the role of inhibition mediated by preNMDARs during epileptogenesis remains unclear. In this study, we wanted to observe the changes in GABAergic inhibition through preNMDARs in sensory-motor and visual cortical pyramidal neurons after pilocarpine-induced status epilepticus.

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