Open AccessRole of Pre-Synaptic NMDA Receptors in the Modulation of Inhibitory Synaptic Transmission in Sensory-Motor and Visual Cortical Pyramidal Neurons in Brain Slices of Young Epileptic Mice
Author(s) -
Muhammad Hanif Che Lah,
Faruque Reza,
Tahamina Begum,
Jafri Malin Abdullah
Publication year - 2018
Publication title -
the malaysian journal of medical sciences/the malaysian journal of medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 25
eISSN - 2180-4303
pISSN - 1394-195X
DOI - 10.21315/mjms2018.25.3.4
Subject(s) - neuroscience , epileptogenesis , inhibitory postsynaptic potential , pilocarpine , neurotransmission , gabaergic , sensory system , visual cortex , nmda receptor , synapse , status epilepticus , motor coordination , chemistry , epilepsy , biology , receptor , medicine
Previous studies from animal models have shown that pre-synaptic NMDA receptors (preNMDARs) are present in the cortex, but the role of inhibition mediated by preNMDARs during epileptogenesis remains unclear. In this study, we wanted to observe the changes in GABAergic inhibition through preNMDARs in sensory-motor and visual cortical pyramidal neurons after pilocarpine-induced status epilepticus.