Open AccessRegulatory T Cells Compensation Failure Cause the Dysregulation of Immune Response in Pristane Induced Lupus Mice Model
Author(s) -
Handono Kalim,
Mirza Zaka Pratama,
Aditya Satriya Nugraha,
Multi Prihartini,
Afriska Chandra,
Al Imroatus Sholihah,
Fatina Qonita,
Kusworini Handono
Publication year - 2018
Publication title -
the malaysian journal of medical sciences/the malaysian journal of medical science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.394
H-Index - 25
eISSN - 2180-4303
pISSN - 1394-195X
DOI - 10.21315/mjms2018.25.3.3
Subject(s) - pristane , autoantibody , immunology , spleen , systemic lupus erythematosus , immune system , pathogenesis , intraperitoneal injection , medicine , autoimmunity , chemistry , antibody , disease , hydrocarbon , organic chemistry
Regulatory T cells' (Tregs') role remains unclear in the pathogenesis of systemic lupus erythematosus (SLE). This study was aimed at monitoring the percentage of Tregs within 32 weeks and monitoring its relationship with the percentage of other T helper (Th) cell subsets and the levels of autoantibodies and pro-inflammatory cytokines in a murine SLE model induced by pristane.