Open AccessHepatocellular Liver Function of Immunosuppressed Rats with Oral Candidiasis after Hyperbaric Oxygen Treatment: Alanine Transaminase and Aspartate Transaminase Levels
Author(s) -
Agni Febrina Pargaputri,
Dwi Andriani
Publication year - 2021
Publication title -
archives of orofacial sciences/archives of orofacial science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.465
H-Index - 2
eISSN - 2231-7163
pISSN - 1823-8602
DOI - 10.21315/aos2021.16.s1.2
Subject(s) - aspartate transaminase , alanine transaminase , liver function , transaminase , medicine , gastroenterology , liver function tests , hyperbaric oxygen , pharmacology , biology , enzyme , anesthesia , biochemistry , alkaline phosphatase
Hepatocellular utility is observed by measuring the hepatocellular enzymes. Changes in its serum levels are related to liver dysfunction. Liver is one of the immunoprotective organs. Continuous use of immunosuppressive drugs can cause oral candidiasis and give effects to liver function. Hyperbaric oxygen treatment (HBOT), while reducing fungal infections, can also repair the liver function. The aim of this study was to investigate the alanine transaminase (ALT) and aspartate transaminase (AST) levels of immunosuppressed rats with oral candidiasis treated with hyperbaric oxygen. Twelve Wistar rats were divided into three groups: K− (normal/ healthy), K+ (oral candidiasis immunosuppressed rats), and P (oral candidiasis immunosuppressed rats treated hyperbaric oxygen). K+ and P groups were immunosuppressed by giving dexamethasone 0.5 mg/day/rat orally for 14 days, added with tetracycline 1 mg/day/rat. HBOT was given in five days successively. Blood serum of rats in all groups were taken to calculate the ALT and AST levels. ALT and AST levels in K+ showed higher value than K− and P groups. The data were analysed with one-way ANOVA test and showed significant difference in ALT levels (p 0.05). This study showed that HBOT affected the ALT and AST levels of immunosuppressed rats with oral candidiasis.