PROGESTERONE INSUFFICIENCY AS A PREDICTOR OF FUTURE REPRODUCTIVE LOSSES

The article presents new data on the significance of vitamin D deficiency in the formation of endometrial structure disorders in women with luteal phase defect and unrupted follicle syndrome. Disorders of the menstrual cycle caused by a progesterone deficiency from the position of influence on the onset and progression of pregnancy are considered. Fertility of women, especially with endocrine imbalances, deserves special attention, since the frequency of early pregnancy loss in them is about 67 %. Aim: study of the effects of vitamin D deficiency and progesterone deficiency in the luteinized unruptured follicle syndrome (Geis-Genes) and the luteal phase defect on the reproductive potential of women. Materials and methods: a hormonal study, determination of vitamin D levels, a sonographic study conducted on days 5–7 and 21–24 of the menstrual cycle in the periconceptional supplementation program of 45 women with luteal phase deficiency (LPD) and luteinized unruptured follicle syndrome (LUF). Results: The relationship between the content of vitamin D and the hormonal levels of the reproductive system of women with LPD and LUF is traced. The role of reducing vitamin D levels in the formation of hormonal imbalances in women of reproductive age has been established. Conclusions: – progesterone deficiency entails changes in various regulatory substances of the reproductive system, and therefore the periconceptional supplementation must be individual. – The introduction of the definition of vitamin D in the periconceptional supplementation plan and its correction are justified and necessary to improve the structure of the endometrium and its secretory transformation in women with progesterone imbalance.