FORECASTING THE DEVELOPMENT OF ACUTE TOXIC EFFECTS IN PROFESSIONAL CONTINGENTS AFTER COMBINED PESTICIDES APPLICATION FOR AGRICULTURAL CROPS PROTECTION

In the overall structure of occupational diseases the large proportion is acute pesticide poisoning (mainly group cases). In recent decades in the structure of agricultural workers’ occupational diseases chemicals poisoning was 14,7-43,5 %. That is why the purpose of the work was to predict the possibility of acute toxic effects on agricultural workers when working with combined formulations. Methods. In order to assess the effects of the aforementioned substances on the workers’ organism the coefficient of possible inhalation poisoning (CIPP), the coefficient of pesticide effect selectivity at inhalation effect (CPESinhal.) and at dermal application (CPESderm.) were used. Results. According to the "Hygienic Classification of Pesticides by Degree of Danger", all studied compounds, as well as combined preparations based on them, are pertained to 4th hazard according to this criterion (CIPP <0,5). Calculated CPESinhal. (103,4-4701,2) and CPESderm. (237,4-12345,7) values for all investigated a.i. were more than 100, which indicates a rather high selectivity of their action. Discussion. Thus, the obtained results allow to predict the possible negative influence of pesticides of different classes on the initial stages of registration tests of pesticide formulations containing studied active substances Conclusion. The importance of observance of the established regulations for formulations application (norms and rates of application) and the obligatory use of the recommended individual protecting means for the respiratory and skin protection by agricultural workers during the application of studied pesticides are shown