Open AccessImmunoassayofantibodies to benzo[a]pyrene, estradiol and progesterone fordeterminationofpersonal lung cancer riskinmen
Author(s) -
А. Н. Глушков,
Е. Г. Поленок,
С. А. Мун,
Л. А. Гордеева,
М. В. Костянко,
Ю. А. Магарилл,
В. А. Титов,
Н. Е. Вержбицкая,
И. А. Вафин
Publication year - 2019
Publication title -
sibirskij onkologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.115
H-Index - 4
eISSN - 2312-3168
pISSN - 1814-4861
DOI - 10.21294/1814-4861-2019-18-2-35-43
Subject(s) - lung cancer , pyrene , immunoassay , medicine , antibody , cancer , lung , endocrinology , chemistry , immunology , organic chemistry
A personalized lung cancer risk assessment is important for disease prevention. The aim of the studywas to estimate a significance of immunoanalysis of antibodies to benzo[a]pyrene, estradiol and progesterone for lung cancer risk prediction in men with respect to age and smoking. Material and methods. Serum antibodies to benzo[a]pyrene, estradiol and progesterone in the blood serum of 620 healthy men (279 smokers) and 827 lung cancer patients (627 smokers) were studied using semi-quantitative enzyme immunoassay. Results. The high lung cancer risk was observed in smokers aged over 55 years: oR=15.4 (11.5–20.8 95 % ci). the lung cancer risk in this group of patients was significantly lower when their levels of antibodies to benzo[a]pyrene and to estradiol were lower than those to progesterone: oR=3.2 (2.0–5.0). the lung cancer risk was higher when the personal levels of antibodies to benzo[a]pyrene and to estradiol were higher than the levels of antibodies to progesterone: oR=20.0 (10.5–38.1). Conclusion. The immunoassay of the blood serum antibodies specific to benzo[a]pyrene, estradiol and progesterone could be useful for determination of the lung cancer risk in men.