Open AccessInfections caused by Clostridium difficile in cancer patients
Author(s) -
И. А. Ключникова,
И. Н. Петухова,
З. В. Григорьевская,
Н. С. Багирова,
И. В. Терещенко,
Н. В. Дмитриева
Publication year - 2019
Publication title -
sibirskij onkologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.115
H-Index - 4
eISSN - 2312-3168
pISSN - 1814-4861
DOI - 10.21294/1814-4861-2018-17-6-92-96
Subject(s) - clostridium difficile , diarrhea , medicine , clostridium , antibiotics , antibiotic associated diarrhea , incidence (geometry) , cancer , clostridiaceae , gastroenterology , microbiology and biotechnology , bacteria , biology , toxin , genetics , physics , optics
The purpose of the study was to determine the role of antibiotics as a risk factor of Clostridium difficile-associated diarrhea in hospitalized cancer patients. Material and Methods . The study included 844 hospitalized cancer patients with diarrhea. The presence of Clostridium difficile toxins A and B in the fecal samples was determined by enzyme immunoassay. Results. Clostridium difficile toxins A and B were detected in 100 cancer patients (42 % men and 58 % women). The incidence of Clostridium difficile-associated diarrhea was higher in women than in men (р<0.02). Patients with hemoblastosis and gastrointestinal tumors were more susceptible to the development of Clostridium difficile associated diarrhea (p<0.02). The use of cephalosporin antibiotics was the main risk factor (р<0.001). In our study, 46 % of the patients took antibiotics. Conclusion. Clostridium difficile was shown to play a significant role in the development of diarrhea in cancer patients, and early detection of Clostridium difficile infection contributes to the early onset of therapy.