Open AccessClinico-pharmacological characteristics of opioid drug-drug interactions in cancer patients with chronic pain syndrome
Author(s) -
О. П. Боброва,
Н. А. Шнайдер,
С. К. Зырянов,
Ю. А. Дыхно,
М. М. Петрова,
Р. Ф. Насырова
Publication year - 2019
Publication title -
sibirskij onkologičeskij žurnal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.115
H-Index - 4
eISSN - 2312-3168
pISSN - 1814-4861
DOI - 10.21294/1814-4861-2018-17-6-114-122
Subject(s) - medicine , analgesic , drug , opioid , cancer pain , chronic pain , intensive care medicine , cancer , pharmacology , physical therapy , receptor
The aim of the review was to analyze published studies on the impact of opioid drug-drug interactions on the choice of analgesic therapy regimens. Material and methods. A systematic literature search was conducted using PubMed, Scopus, Web of Science, and E-library databases. Results. The review showed a clinical significance of pharmacokinetic interactions of opioids with other drugs in cancer pain treatment. The problems of individual choice of analgesics from different groups under conditions of co-morbidity and concomitant medication were discussed to ensure the effectiveness/safety of the treatment strategy affecting the quality of life of cancer patients. Conclusion. A comprehensive assessment of factors in patients receiving opioid analgesics is a predictor of effective and safe analgesic therapy.