Open AccessClofazimine: History and Perspectives
Author(s) -
Г. Н. Можокина,
Anastasia Samoilova
Publication year - 2021
Publication title -
tuberkulez i bolezni lëgkih/tuberkulëz i bolezni lëgkih
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.226
H-Index - 12
eISSN - 2542-1506
pISSN - 2075-1230
DOI - 10.21292/2075-1230-2021-99-5-64-70
Subject(s) - clofazimine , mycobacterium tuberculosis , tuberculosis , drug , pharmacokinetics , medicine , pharmacology , drug discovery , computational biology , leprosy , biology , bioinformatics , immunology , pathology
The review analyses 47 publications that follow the pathway of clofazimine from its discovery to recognition as a Group B drug for treatment of multiple drug resistant tuberculosis. It describes its mechanism of action and effects on Mycobacterium tuberculosis, pharmacokinetics, and safety parameters.