Open AccessPhotodynamic therapy in tuberculous pleural empyema
Author(s) -
С. Д. Никонов,
M N. Smolentsev,
Д. В. Краснов,
D. А. Bredikhin,
С. Н. Белогородцев
Publication year - 2021
Publication title -
tuberkulez i bolezni lëgkih/tuberkulëz i bolezni lëgkih
Language(s) - English
Resource type - Journals
eISSN - 2542-1506
pISSN - 2075-1230
DOI - 10.21292/2075-1230-2021-99-5-51-56
Subject(s) - medicine , empyema , bronchopleural fistula , photodynamic therapy , pleural cavity , surgery , antimicrobial , fistula , pleural empyema , tuberculosis , microbiology and biotechnology , pathology , lung , pneumonectomy , chemistry , organic chemistry , biology
as a lethal outcome predictor. To enhance treatment efficacy, TPE local sanitation method utilizing antimicrobial photodynamic therapy (PDT) has been developed. This technique is based on the generation of oxygen radicals by the interaction of photosensitizers and light quanta which inactivate Mycobacterium tuberculosis and pyogenic flora. To assess the sanitizing and antimicrobial efficacy of PDT, 96 procedures were performed in 16 patients (in 14 cases, TPE was complicated by bronchopleural fistula, in 10 cases it developed after surgical treatment of pulmonary tuberculosis). After intrapleural instillation of phthalocyanine aluminum 0.5 mg, all walls of the empyema cavity were irradiated by laser radiation with the wavelength of 662 nm and light density of 30-100 J/cm2. The response to PDT of tuberculous pleural empyema was reported in 93.75% of cases (n = 15), with complete response observed in 75% of cases (n = 12).