Open AccessCommunity-acquired pneumonia in HIV patients
Author(s) -
И. Б. Викторова,
В. Н. Зимина,
И В Дадыка,
Irina V. Andreeva,
И. А. Головина,
Е. П. Чужикова
Publication year - 2021
Publication title -
tuberkulez i bolezni lëgkih/tuberkulëz i bolezni lëgkih
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.226
H-Index - 12
eISSN - 2542-1506
pISSN - 2075-1230
DOI - 10.21292/2075-1230-2021-99-4-22-28
Subject(s) - medicine , leukocytosis , community acquired pneumonia , leukopenia , pneumonia , immunosuppression , bacteremia , retrospective cohort study , gastroenterology , lymphocytopenia , surgery , respiratory failure , antibiotics , chemotherapy , lymphocyte , microbiology and biotechnology , biology
The objective : to study the frequency and nature of community-acquired pneumonia (CAP) in HIV patients. Subjects and methods : The continuous longitudinal retrospective study of all cases of respiratory diseases among HIV patients (n = 185), who received in-patient treatment in the therapy department. Results . CAP was diagnosed in 38.4% (n = 71) of patients and it was the most frequent respiratory disease among HIV patients. The median CD4 count in CAP made 197.5 cells/μL, 9.1% of patients received antiretroviral therapy before hospital admission. 74.7% of CAP patients (n = 53) had lesions disseminated to several lobes. Laboratory parameters revealed in severe CAP (leukocytosis > 12 × 109/L, leukopenia 0.05). Bacteremia in CAP was detected in 20.8% of patients and it was associated with the failure of standard empiric antibiotic therapy (p < 0.05). 9.9% of CAP patients (n = 7) were diagnosed with polymicrobial infection. Lethal outcomes of CAP were recorded in 5.6% of cases (n = 4), all with severe immunosuppression (the median of CD4 count was 5 cells/μL), 2 cases had bilateral subtotal CAP and 2 suffered from polymicrobial infection.