Open AccessPossibilities of specific immunological tests in patients with TB/HIV coinfection
Author(s) -
Л. Н. Мотанова,
M. S. Grabovskaya,
I. V. Folts
Publication year - 2021
Publication title -
tuberkulez i bolezni lëgkih/tuberkulëz i bolezni lëgkih
Language(s) - English
Resource type - Journals
eISSN - 2542-1506
pISSN - 2075-1230
DOI - 10.21292/2075-1230-2021-99-10-46-51
Subject(s) - coinfection , tuberculosis , medicine , human immunodeficiency virus (hiv) , mycobacterium tuberculosis , immunology , tuberculosis diagnosis , skin test , gastroenterology , pathology
The objective of the study: to study the possibilities of skin tests with tuberculosis recombinant allergen (TRA) in the diagnosis of tuberculosis in HIV-positive patients in the region with a high prevalence of tuberculosis. Subjects and Methods. Medical les of 85 patients were retrospectively analyzed, all the patients suered from TB/HIV coinfection and underwent the skin test with TRA. Results. The skin test with TRA was found to be signicantly valuable for the diagnosis of tuberculosis in patients with TB/HIV coinfection. The correlation between the intensity of response to the TRA test and CD4 + count was detected ( p = 0.011). The lowest values were observed for CD4 + counts below 100 cells/μL. The direct correlation between the intensity of response to TRA and the stage of HIV infection was proved. No eect of the form of tuberculosis, the phase of the tuberculosis disease, or drug sensitivity on the intensity of response to TRA was found. Among tuberculosis patients with bacterial excretion ( n = 48), 68.8% of patients responded positively to the TRA test, and in those with no bacterial excretion, the positive reaction was observed in 81.1%.