Open AccessAssessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study
Author(s) -
А. А. Визель,
Д. А. Калвер,
И. Ю. Визель,
Г. Р. Шакирова,
Е. А. Бакунина
Publication year - 2020
Publication title -
tuberkulez i bolezni lëgkih/tuberkulëz i bolezni lëgkih
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.226
H-Index - 12
eISSN - 2542-1506
pISSN - 2075-1230
DOI - 10.21292/2075-1230-2020-98-10-33-40
Subject(s) - medicine , sarcoidosis , stage (stratigraphy) , alpha tocopherol , tocopherol , pulmonary sarcoidosis , gastroenterology , nuclear medicine , surgery , vitamin e , paleontology , biochemistry , chemistry , biology , antioxidant
The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment. Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46). Conclusion. The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment.