Open AccessBIOAVAILABILITY ENHANCEMENT AND LIPID NANOCARRIER BASED DELIVERY OF PEPTIDES AND PROTEINS
Author(s) -
Sunita Dahiya,
Rajiv Dahiya
Publication year - 2020
Publication title -
bulletin of pharmaceutical research
Language(s) - English
Resource type - Journals
eISSN - 2249-9245
pISSN - 2249-6041
DOI - 10.21276/bpr.2020.10.3
Subject(s) - nanocarriers , bioavailability , biocompatible material , drug delivery , membrane permeability , peptide , chemistry , nanotechnology , pharmacology , biochemistry , membrane , materials science , medicine , biomedical engineering
Peptides and proteins are vital biomacromolecules that perform several bodily functions in various physiological and biological processes. Being biocompatible and biodegradable, these macromolecules are considered promising platforms for delivery of drugs and genes. However, peptides and proteins suffer from major limitations including enzymatic degradation, short circulation half-lives, and poor membrane permeability that leads to poor bioavailability, challenging their effective delivery. This article briefly discusses the inherent challenges in peptide and protein delivery along with strategies for bioavailability enhancement and lipid nanocarriers as prospective systems for peptide and protein drug delivery.