Open AccessBIOCHEMICAL AND HISTOPATHOLOGICAL INVESTIGATIONS OF HEPATOPROTECTIVE POTENTIAL OF Phoenix dactylifera AGAINST ISONIAZID INDUCED TOXICITY IN ANIMAL MODEL
Author(s) -
Asif Hussain
Publication year - 2019
Publication title -
pakistan journal of agricultural sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.22
H-Index - 20
eISSN - 2076-0906
pISSN - 0552-9034
DOI - 10.21162/pakjas/19.6097
Subject(s) - phoenix dactylifera , catalase , palm , traditional medicine , isoniazid , toxicity , pharmacology , liver function , medicine , toxicology , biology , chemistry , enzyme , biochemistry , pathology , tuberculosis , physics , quantum mechanics
Phoenix dactylifera (Ajwa khajur) is pharmacologically important plant because of its hepatoprotective, nephroprotective, gastroprotective, antihyperlipidemic and anticancerous properties. In present study, hepatoprotective effect of Phoenix dactylifera was observed in adult albino rabbits. Isoniazid (INH) is a first line antitubercular agent but it has hepatotoxicity causing potential due to the generation of reactive oxygen species on its prolong use. Thirty adult albino rabbits of either sex were used in this study. Hepatoprotective potential of date palm was screened by using its two doses i.e. 150mg/kg/day and 300mg/kg/day up to 14 days. Results have shown that experimental animals treatment with date palm significantly prevented elevation of liver function enzymes (AST, ALT and ALP). Alteration in oxidative status parameters (TAC, TOS, MDA and catalase) significantly prevented as compared to isoniazid induced hepatotoxic animals. Also, complete blood count evaluation showed increase in blood cells number. All above findings were also confirmed by histopathological studies. Liver tissue samples showed normal hepatocytes architecture in date palm treated groups. Therefore, from the results we can conclude that Phoenix dactylifera fruit possesses hepatoprotective activity and have a mild hematopoietic effect.