Open AccessEvaluation of quality change in Salviae miltiorrhizae radix et rhizoma during drying by LF-NMR and HPLC
Author(s) -
Qinrong Liu,
Yi-Shuo Wang,
Zhenling Zhang,
Zuliang Du,
Jiazhen Li,
Yuquan Wu
Publication year - 2022
Publication title -
analytical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.392
H-Index - 73
eISSN - 1348-2246
pISSN - 0910-6340
DOI - 10.2116/analsci.21p169
Subject(s) - chemistry , radix (gastropod) , high performance liquid chromatography , chromatography , partial least squares regression , moisture , traditional medicine , organic chemistry , botany , medicine , statistics , mathematics , biology
Salviae miltiorrhizae radix et rhizoma (Danshen, in Chinese) is one of the traditional Chinese medicines commonly used in clinical practice. In this study, low field nuclear magnetic resonance (LF-NMR) was used to detect changes in the moisture content during the drying of Danshen. Three water states (bound, immobilized, and free) in Danshen were investigated by multi-exponential fitting of the NMR data. Mass changes during drying were analyzed using high-performance liquid chromatography and partial least squares discriminant analysis. The results revealed that two components, salvianolic acid B and tanshinone, were the main chemical substances that produced the differences. Correlations were found among chemical substances, color, and moisture. LF-NMR can quickly assess the moisture content during drying. It also provides a practical tool for the production and processing of medicines or slices.