Open AccessMitochondrial malic enzyme 2 promotes breast cancer metastasis via stabilizing HIF-1α under hypoxia
Author(s) -
Duo You,
Dan-Feng Du,
Xueke Zhao,
Xinmin Li,
Minfeng Ying,
Xun Hu
Publication year - 2021
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2021.03.03
Subject(s) - breast cancer , downregulation and upregulation , metastasis , gene knockdown , cancer research , cancer , in vivo , knockout mouse , immunohistochemistry , medicine , cancer cell , apoptosis , endocrinology , chemistry , biology , receptor , biochemistry , microbiology and biotechnology , gene
α-ketoglutarate (α-KG) is the substrate to hydroxylate collagen and hypoxia-inducible factor-1α (HIF-1α), which are important for cancer metastasis. Previous studies have shown that the upregulation of collagen prolyl 4-hydroxylase in breast cancer cells stabilizes the expression of HIF-1α by depleting α-KG levels. We hypothesized that mitochondrial malic enzyme 2 (ME2) might also affect HIF-1α expression via modulating α-KG levels in breast cancer cells.