Open AccessLandscape of cell heterogeneity and evolutionary trajectory in ulcerative colitis-associated colon cancer revealed by single-cell RNA sequencing
Author(s) -
Quan Wang,
Weiming Zhu,
Zhen Zhang,
Wei Zhang,
Mengmeng Zhang,
Zhanlong Shen,
Yingjiang Ye,
Kewei Jiang,
Shan Wang
Publication year - 2021
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2021.02.13
Subject(s) - ulcerative colitis , biology , cell , transcriptome , colorectal cancer , cancer research , gene , stromal cell , cancer , cancer cell , rna , disease , gene expression , genetics , medicine , pathology
The goal of this study was to get preliminary insight on the intra-tumor heterogeneity in colitis-associated cancer (CAC) and to reveal a potential evolutionary trajectory from ulcerative colitis (UC) to CAC at the single-cell level.