Open AccessCombined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer
Author(s) -
Hongyan Cheng,
Shang Wang,
Wenqing Luan,
Yu Xue,
Sha Dou,
Zhijian Tang,
Honglan Zhu,
Peter Ping Lin,
Yi Li,
Heng Cui,
Xiaohong Chang
Publication year - 2021
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2021.02.12
Subject(s) - fluorescence in situ hybridization , circulating tumor cell , pathology , medicine , ovarian cancer , metastasis , aneuploidy , immunostaining , oncology , cancer , chromosome , biology , immunohistochemistry , gene , genetics
Hematogenous metastasis is essential for the progression of ovarian cancer (OC), and circulating tumor cells (CTCs) are part of the metastatic cascade. However, the detection rate of CTC is low due to the use of less sensitive detection methods. Therefore, this study aimed to detect CTCs and circulating tumorigenic endothelial cells (CTECs) in patients with OC using subtraction enrichment and immunostaining and fluorescence in situ hybridization (SE-iFISH).