Open AccessTim-3 promotes cell aggressiveness and paclitaxel resistance through NF-κB/STAT3 signalling pathway in breast cancer cells
Author(s) -
Yizi Cong,
Yuxin Cui,
Shiguang Zhu,
Jianqiao Cao,
Haidong Zou,
Tracey Amanda Martin,
Guangdong Qiao,
Wen Guo Jiang,
Zhengping Yu
Publication year - 2020
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2020.05.02
Subject(s) - breast cancer , cancer research , downregulation and upregulation , cyclin d1 , mmp1 , occludin , medicine , stat3 , cancer , biology , signal transduction , tight junction , cell cycle , gene expression , microbiology and biotechnology , biochemistry , gene
Although T-cell immunoglobulin and mucin-domain containing molecule-3 (Tim-3) has been recognized as a promising target for cancer immunotherapy, its exact role in breast cancer has not been fully elucidated.