Open AccessDefect of SLC38A3 promotes epithelial mesenchymal transition and predicts poor prognosis in esophageal squamous cell carcinoma
Author(s) -
Rui Li,
Ruoxi Hong,
Yan Wang,
Ying Gong,
Danna Yeerken,
Dian Yang,
Jinting Li,
Jingyuan Fan,
Jie Chen,
Weimin Zhang,
Qimin Zhan
Publication year - 2020
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2020.05.01
Subject(s) - cancer research , biology , immunohistochemistry , western blot , somatic cell , gene knockdown , phenotype , gentamicin protection assay , cell culture , microbiology and biotechnology , gene , genetics , immunology
Solute carrier family 38 (SLC38s) transporters play important roles in amino acid transportation and signaling transduction. However, their genetic alterations and biological roles in tumors are still largely unclear. This study aimed to elucidate the genetic signatures of SLC38s transporters and their implications in esophageal squamous cell carcinoma (ESCC).