Open AccessAdipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways
Author(s) -
Wenzhong Zhou,
Chunmiao Ye,
Liang Li,
Liyuan Liu,
Fei Wang,
Shude Cui,
Fei Zhou,
Yuzhi Xiang,
Yongjiu Wang,
Gengshen Yin,
Zhongbing Ma,
Qinye Fu,
Qiang Zhang,
Dezong Gao,
Shuya Huang,
Yu Zhang
Publication year - 2020
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2020.03.06
Subject(s) - breast cancer , wnt signaling pathway , epithelial–mesenchymal transition , adipokine , cancer research , medicine , metastasis , adipocyte , endocrinology , oncology , cancer , signal transduction , adipose tissue , biology , insulin resistance , microbiology and biotechnology , obesity
Obesity is closely associated with metastasis in breast cancer patients. Secreted frizzled-related protein 5 (SFRP5), one of the novel adipokines with anti-inflammatory properties, is associated with obesity. This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.