Open AccessLow-depth whole genome sequencing reveals copy number variations associated with higher pathologic grading and more aggressive subtypes of lung non-mucinous adenocarcinoma
Author(s) -
Zheng Wang,
Lin Zhang,
Lei He,
Di Cui,
Chenglong Liu,
Liangyu Yin,
Min Zhang,
Lei Jiang,
Yuyan Gong,
Wei Wu,
Lei Bi,
Xiaoyü Li,
David S. Cram,
Dongge Liu
Publication year - 2020
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2020.03.05
Subject(s) - grading (engineering) , adenocarcinoma , laser capture microdissection , copy number variation , chromosome instability , microdissection , lung cancer , pathology , medicine , lung , histology , biology , chromosome , oncology , genome , gene , cancer , genetics , gene expression , ecology
Histology grade, subtypes and TNM stage of lung adenocarcinomas are useful predictors of prognosis and survival. The aim of the study was to investigate the relationship between chromosomal instability, morphological subtypes and the grading system used in lung non-mucinous adenocarcinoma (LNMA).