Open AccessGenomic dissection of gastrointestinal and lung neuroendocrine neoplasm
Author(s) -
Shuangfeng Wang,
Li Sun,
Hua Bao,
Ao Wang,
Panpan Zhang,
Xue Wu,
Xiaoling Tong,
Xiaonan Wang,
Jie Luo,
Senjie Lin,
Yang Shao,
Ming Lu
Publication year - 2019
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2019.06.08
Subject(s) - chromosome instability , exome sequencing , biology , neuroendocrine tumors , genome instability , comparative genomic hybridization , lung , copy number variation , lung cancer , cancer research , gene duplication , mutation , cancer , medicine , gene , chromosome , genetics , genome , dna , dna damage
Neuroendocrine neoplasms (NENs) are relatively rare and heterogeneous malignancies with two major subtypes: low-grade neuroendocrine tumor (NET) and high-grade neuroendocrine carcinoma (NEC). Comprehensive molecular characterization of NENs is needed to refine our understanding of the biological underpinnings of different NEN subtypes and to predict disease progression more accurately.