Open AccessSynthesis and evaluation of 64Cu-radiolabeled NOTA-cetuximab (64Cu-NOTA-C225) for immuno-PET imaging of EGFR expression
Author(s) -
Xiaoxia Xu,
Teli Liu,
Fei Liu,
Xiaoyi Guo,
Liangping Xia,
Qing Xie,
Nan Li,
Haifeng Huang,
Xinyu Yang,
Yangchun Xin,
Hua Zhu,
Zhi Yang
Publication year - 2019
Publication title -
chinese journal of cancer research/chinese journal of cancer research
Language(s) - English
Resource type - Journals
eISSN - 1993-0631
pISSN - 1000-9604
DOI - 10.21147/j.issn.1000-9604.2019.02.14
Subject(s) - cetuximab , chemistry , epidermal growth factor receptor , positron emission tomography , in vivo , a431 cells , nuclear medicine , pet imaging , cancer research , cancer , receptor , medicine , colorectal cancer , biology , biochemistry , cell , oncogene , cell cycle , microbiology and biotechnology
Epidermal growth factor receptor (EGFR) is overexpressed in a wide variety of solid tumors, serving as a well-characterized target for cancer imaging or therapy. In this study, we aimed to design and synthesize a radiotracer, 64 Cu-NOTA-C225, targeting EGFR for tumor positron emission tomography (PET) imaging.