Open AccessFeatures of the human immune response to Helicobacter pylori infection
Author(s) -
В. В. Новиков,
В А Лапин,
Д. А. Мелентьев,
Е В Мохонова
Publication year - 2019
Publication title -
medialʹ
Language(s) - English
Resource type - Journals
ISSN - 2225-0026
DOI - 10.21145/2225-0026-2019-2-55-69
Subject(s) - immune system , immunology , acquired immune system , biology , helicobacter pylori , inflammation , innate immune system , gastric mucosa , immunity , ccl18 , gastritis , stomach , genetics , biochemistry
Helicobacter pylori is considered the etiological agent of acute and chronic forms of gastritis, and is also capable of exerting a multifactorial effect on the host organism and on the nature of the immune response. The inflammatory response to H. pylori infection has its own characteristics. With an active course, inflammatory reactions, when the modulating effect of regulatory T-lymphocytes (T-reg) is weakened and populations of pro-inflammatory cells (T-helpers 1, 17, 22 type and follicular T-helpers) are activated, which have pronounced destructive changes in the gastric mucosa and the duodenum. guts. Macrophages, dendritic cells and neutrophils are cellular factors of the innate immune system, as well as adaptive immunity, which provides protection against infection. In turn, H. pylori uses a variety of mechanisms to evade the destruction of the host immune system. Long-term preservation of inflammation can cause local activation of mutagenesis, which initiates the development of malignant neoplasms of the gastric mucosa. A review of the host immune response to H. pylori is devoted to this analytical review.