Open AccessMetaplastic Carcinoma with Mesenchymal Differentiation in Augmented Breast using Liquid Silicone Injection: A Case Report
Author(s) -
Lara Mae Lorenzo,
Sarah Jane Datay-Lim,
Jose M. Carnate
Publication year - 2020
Publication title -
philippine journal of pathology (print)/philippine journal of pathology (online)
Language(s) - English
Resource type - Journals
eISSN - 0118-3265
pISSN - 2507-8364
DOI - 10.21141/pjp.2020.10
Subject(s) - mesenchymal stem cell , malignancy , breast carcinoma , silicone , breast cancer , cd34 , pathology , medicine , carcinoma , cancer , chemistry , biology , stem cell , organic chemistry , genetics
The relationship between the use of liquid silicone for breast augmentation and carcinogenesis remains undetermined due to limited data reported, especially regarding its risks for acquiring cancer. We documented a case of an 81-year-old woman who presented with bilateral enlarging breast masses with a known history of breast augmentation using liquid silicone. On microscopic examination, the malignancy showed both mesenchymal and epithelial components in a background of stromal changes related to liquid silicone. Based from morphology and immunohistochemistry studies (p63, CK, HMW-CK, and CK5/6, CD34, and BcL-2), this case was signed out as metaplastic carcinoma with mesenchymal differentiation. This rare case of metaplastic carcinoma with mesenchymal differentiation coexisting with liquid silicone, provides evidence supporting the link between cancer development and siliconomas.