Open AccessSynthesis of New Heterocyclic Compounds Derived from Anthrone and Evaluation of Their Biological Activity
Author(s) -
Nadia Salih
Publication year - 2008
Publication title -
mağallaẗ baġdād li-l-ʿulūm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 6
eISSN - 2411-7986
pISSN - 2078-8665
DOI - 10.21123/bsj.5.4.627-637
Subject(s) - anthrone , chemistry , candida albicans , bacteria , nucleophile , schiff base , carbon 13 nmr , escherichia coli , organic chemistry , stereochemistry , microbiology and biotechnology , biology , biochemistry , catalysis , genetics , gene
In this research, Schiff bases derived from the reaction of anthrone with different heterocyclic amines have been described. The resulted Schiff base compounds were reacted with various nucleophiles in order to obtain new heterocyclic derivatives. Chemical structures of all products were confirmed by IR, 1H-, 13C-NMR spectral data and elemental analysis. All synthesized compounds were in vitro tested against a standard strain of pathogenic microorganism including Gram +ve bacteria (Staphylococcus aureus), Gram –ve bacteria (Escherichia coli), and fungi (Candida albicans).