Open AccessSpectrophotometric Analytical method for Determination the Drug Compound Salbutamol by using Prussian blue Complex
Author(s) -
Baghdad Science Journal
Publication year - 2014
Publication title -
mağallaẗ baġdād li-l-ʿulūm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 6
eISSN - 2411-7986
pISSN - 2078-8665
DOI - 10.21123/bsj.11.2.303-310
Subject(s) - prussian blue , potassium ferricyanide , chemistry , chromatography , calibration curve , salbutamol , detection limit , volume (thermodynamics) , chloride , nuclear chemistry , inorganic chemistry , organic chemistry , medicine , physics , electrode , quantum mechanics , asthma , electrochemistry
This research aims to develop new spectrophotometric analytical method to determine drug compound Salbutamol by reaction it with ferric chloride in presence potassium ferricyanide in acid median to formation of Prussian blue complex to determine it by uv-vis spectrophotmetric at wavelengths rang(700-750)nm .Study the optimal experimental condition for determination drug and found the follows:1- Volume of(10M) H2SO4 to determine of drug is 1.5 ml .2- Volume and concentration of K3Fe(CN)6 is 1.5 ml ,0.2% .3- Volume and concentration of FeCl3 is 2.5ml , 0.2%.4- Temperature has been found 80 .5- Reaction time is 15 minute .6- Order of addition is (drug + K3Fe(CN)6+ FeCl3 + acid) .Concentration rang (0.025-5 ppm) , limit detection(0.02)ppm .The method was applied successfully to determine the drug in tablet pharmaceutical preparation by use direct calibration curve and standard addition curve the recovery was 98.5% .