Open AccessSpectrophotometric method for the determination of Captopril in pharmaceutical formulations
Author(s) -
Dawood H. Mohammed,
Intesar A. Shehab,
Hend O. Ahmed
Publication year - 2013
Publication title -
mağallaẗ baġdād li-l-ʿulūm
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.167
H-Index - 6
eISSN - 2411-7986
pISSN - 2078-8665
DOI - 10.21123/bsj.10.3.965-970
Subject(s) - captopril , molar absorptivity , chromatography , chemistry , aqueous solution , absorption (acoustics) , materials science , organic chemistry , optics , medicine , physics , blood pressure , composite material
A simple, rapid and sensitive spectrophotometric method has been developed for the determination of captopril in aqueous solution. The method is based on reaction of captopril with 2,3-dichloro 1,4- naphthoquinon(Dichlone) in neutral medium to form a stable yellow colored product which shows maximum absorption at 347 nm with molar absorptivity of 5.6 ×103 L.mole-1. cm-1. The proposed method is applied successfully for determination of captopril in commercial pharmaceutical tablets.