Open AccessThe Possible Role of Herpesviruses in the Pathogenesis of Coronary Atherosclerosis
Author(s) -
Julia Kotova,
Veronika I. Shevzova,
А. А. Зуйкова,
Olga Krasnorutskaya,
Natalia Strahova,
Elena Yu. Esina
Publication year - 2021
Publication title -
international journal of biomedicine
Language(s) - English
Resource type - Journals
eISSN - 2158-0529
pISSN - 2158-0510
DOI - 10.21103/article11(4)_ra1
Subject(s) - pathogenesis , medicine , asymptomatic , coronary atherosclerosis , coronary artery disease , cause of death , etiology , disease , angina , endothelial dysfunction , sudden death , coronary arteries , cardiology , myocardial infarction , artery
Cardiovascular diseases are still the dominant cause of death worldwide. Coronary artery disease (CAD) is the most common type of heart disease and the leading cause of death for both men and women. Coronary atherosclerosis underlies multiple clinical manifestations ranging from asymptomatic to stable angina, acute coronary syndrome, MI, heart failure, and sudden cardiac death. The prerequisites for a closer study of the pathogenesis of the atherosclerotic process were the development of atherosclerotic vascular lesions at a younger age and the rapid progression of the process. Currently, it is generally accepted that CAD is a multifactorial disease. Attention is drawn to hereditary disorders of the receptor apparatus, endothelial dysfunction, and lipid metabolism disorders. In addition, latent viral infections are one of the etiopathogenetic factors in the development of atherosclerosis. A number of scientific studies have confirmed the relationship between infectious agents and the development of atherosclerotic vascular lesions. The viral etiology of the development and progression of atherosclerosis is the subject of debate among scientists around the world.